Adaptations of Skeletal Muscle Mitochondria to Obesity, Exercise, and Polyunsaturated Fatty Acids. Issue 3 (16th April 2018)

• Record Type: Journal Article
• Authors: Chen, Phoebe B.; Yang, Jason S.; Park, Yeonhwa
• Is Part Of: Lipids. Volume 53:Issue 3(2018)
• Page Start: 271
• Page End: 278
• Publication Date: 2018-04-16
• Subjects: CLA -- Conjugated linoleic acid -- Exercise mimetics -- Mitochondrial dynamics; Lipids -- Periodicals; Lipids -- Periodicals; Lipiden; Lipides -- Périodiques; 547.77
• DOI: 10.1002/lipd.12037
• Languages: English
• ISSNs: 0024-4201

Abstract

Abstract: Mitochondria intricately modulate their energy production through the control of mitochondrial adaptation (mitochondrial biogenesis, fusion, and/or fission) to meet energy demands. Nutrient overload may result in dysregulated mitochondrial biogenesis, morphology toward mitochondrial fragmentation, and oxidative stress in the skeletal muscle. In addition, physical activity and diet components influence mitochondrial function. Exercise may stimulate mitochondrial biogenesis and promote mitochondrial fusion/fission in the skeletal muscle. Moreover, some dietary fatty acids, such as n‐3 polyunsaturated fatty acids and conjugated linoleic acid, have been identified to positively regulate mitochondrial adaptation in the skeletal muscle. This review discusses the association of mitochondrial impairments and obesity, and presents an overview of various mechanisms of which exercise training and mitochondrial nutrients promote mitochondrial function in the skeletal muscle.