Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review. (August 2015)

• Record Type: Journal Article
• Authors: Di Napoli, Arianna; Mallel, Giuseppe; Bartolazzi, Armando; Cavalieri, Elena; Becelli, Roberto; Cippitelli, Claudia; Ruco, Luigi
• Is Part Of: International journal of surgical pathology. Volume 23:Number 5(2015)
• Page Start: 419
• Page End: 423
• Publication Date: 2015-08
• Subjects: nodular predominant Hodgkin lymphoma -- Warthin tumor -- parotid gland -- collision tumor; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896915582263
• Languages: English
• ISSNs: 1066-8969

Abstract

Hodgkin lymphoma (HL) associated with Warthin tumor (WT) is extremely rare, accounting for only 3 cases of classical HLs. Here, we report for the first time the occurrence of a nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) involving the lymphoid stroma of a WT of the parotid gland. Pathogenesis of WT is controversial, with both a nodal and a parenchymal possible origin. On the other hand, extranodal involvement by HLs is uncommon. In our case, the coexistence of a WT and of a NLPHL within its stroma and in cervical lymph node emphasizes the importance of a careful evaluation of the lymphoid tissue in WT in order to exclude the possibility of an associated lymphoid malignancy.