A-102 Antibody binding to HIV-1 infected cells as mechanism for treatment of HIV infection. (April 2018)

• Record Type: Journal Article
• Authors: Ferrari, Guido; Nordstrom, Jeffrey; Koenig, Scott; Sung, Julia; Margolis, David; Haynes, Barton
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 77(2018)Supplement 1
• Publication Date: 2018-04
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/01.qai.0000532483.69631.d6
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Anti-HIV antibody function is not limited to capturing free virus but also includes the recognition of HIV-1 infected cells. Both neutralizing and nonneutralizing antibody responses recognizing HIV-1 envelope epitopes expressed on the cellular membrane can recruit Fc receptor-bearing cells and direct their cytotoxic activity against the infected cells. We can leverage on our ability to use monoclonal antibody and monoclonal antibody-based molecules to protect from and treat HIV-1 infection.