Preparation and blood compatibility of electrospun nanofibrous CTS/PLA mats from chitosan nanopowders and poly(lactic acid). (19th July 2017)

• Record Type: Journal Article
• Authors: Dong, Wenyuan; Zeng, Qinhuan; Yin, Xueqiong; Liu, Haifang; Lv, Ju; Zhu, Li
• Is Part Of: Polymer composites. Volume 39(2018)Supplement 1
• Page Start: E416
• Page End: E425
• Publication Date: 2017-07-19
• Subjects: Polymeric composites -- Periodicals; 620.192
• DOI: 10.1002/pc.24500
• Languages: English
• ISSNs: 0272-8397

Abstract

Abstract : Chitosan nanopowder (NCTS) was prepared through ball milling. NCTS was successfully electrospun to nanofibers with the assistance of poly(lactic acid) (PLA) to prepare electrospun mats (NCTS/PLA). Scanning electron microscope images revealed that there were no chitosan particles in NCTS/PLA, indicating NCTS had been stretched to nanofibers. The effects of the electrospinning parameters (voltage, distance, and NCTS amount) on the morphology of NCTS/PLA were investigated. X‐ray photoelectron spectroscopy verified the existence of chitosan in the mats. All the NCTS/PLA mats had a water contact angle higher than 130°, showing good hydrophobicity. NCTS/PLA expressed good blood compatibility according to the results of coagulation time and platelet adhesion experiment. NCTS/PLA had a little longer activated partial thrombin time than PLA and more NCTS leaded longer coagulation times. No platelets aggregation and deformation appeared on NCTS/PLA mats. POLYM. COMPOS., 39:E416–E425, 2018. © 2017 Society of Plastics Engineers