Effects of oral contraceptives on ovulation induction in in vitro fertilization patients with premature ovarian insufficiency. (4th May 2018)

• Record Type: Journal Article
• Authors: Chen, M.; Han, H.; Chuai, Y.; Hao, M.; Shu, M.; Shang, W.
• Is Part Of: Climacteric. Volume 21:Number 3(2018)
• Page Start: 276
• Page End: 279
• Publication Date: 2018-05-04
• Subjects: Oral contraceptives -- premature ovarian insufficiency -- premature ovarian failure -- ovulation induction -- infertility; Menopause -- Periodicals; Menopause -- Hormone therapy -- Periodicals; Menopause -- Periodicals; Estrogen Replacement Therapy -- Periodicals; Gynecology -- Periodicals; Societies, Medical -- Periodicals; 612.665
• DOI: 10.1080/13697137.2018.1439912
• Languages: English
• ISSNs: 1369-7137

Abstract

Abstract: Objective: To report a case series of in vitro fertilization patients with premature ovarian insufficiency, who were treated with oral contraceptives to reduce follicle stimulating hormone levels. Method: This was a consecutive case series in a tertiary teaching hospital in China. Twenty-two women with refractory and idiopathic premature ovarian insufficiency were administered a drospirenone/ethinylestradiol oral contraceptive orally. The main outcome measures were the number of oocytes retrieved and the number of embryos frozen. Results: There were total 106 oral contraceptive treatment cycles and 53 oocyte retrieval cycles in 20 patients (91%, 20/22; 2.4 cycles per woman, 53/22). The total number of oocytes retrieved was 48 in 17 patients (77%, 17/22; 2.2 oocytes per woman, 48/22), and the total number of embryos frozen was 33 in 16 patients (73%, 16/22; 1.5 embryos per woman, 33/22). Conclusion: Oral contraception may be an effective method to induce ovulation for some patients with premature ovarian insufficiency.