Biomedical Informatics on the Cloud: A Treasure Hunt for Advancing Cardiovascular Medicine. Issue 9 (27th April 2018)

• Record Type: Journal Article
• Authors: Ping, Peipei; Hermjakob, Henning; Polson, Jennifer S.; Benos, Panagiotis V.; Wang, Wei
• Is Part Of: Circulation research. Volume 122:Issue 9(2018)
• Publication Date: 2018-04-27
• Subjects: cardiovascular disease -- environment -- informatics -- machine learning -- metadata; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.117.310967
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : In the digital age of cardiovascular medicine, the rate of biomedical discovery can be greatly accelerated by the guidance and resources required to unearth potential collections of knowledge. A unified computational platform leverages metadata to not only provide direction but also empower researchers to mine a wealth of biomedical information and forge novel mechanistic insights. This review takes the opportunity to present an overview of the cloud-based computational environment, including the functional roles of metadata, the architecture schema of indexing and search, and the practical scenarios of machine learning–supported molecular signature extraction. By introducing several established resources and state-of-the-art workflows, we share with our readers a broadly defined informatics framework to phenotype cardiovascular health and disease.