Synthesis of novel sugar or azasugar modified anthra[1, 2-d] imidazole-6, 11-dione derivatives and biological evaluation. (2nd May 2018)

• Record Type: Journal Article
• Authors: Wang, Qiwei; Ma, Chen; Li, Xueyan; Wang, Xiaofen; Rong, Ruixue; Wei, Chao; Zhang, Pingzhu; Li, Xiaoliu
• Is Part Of: Carbohydrate research. Volume 460(2018)
• Page Start: 29
• Page End: 33
• Publication Date: 2018-05-02
• Subjects: C-nucleoside -- Sugar -- Azasugar -- Anthra[1, 2-d]imidazole-6, 11-dione -- HIV-RT inhibition -- Cytotoxicity; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2018.02.012
• Languages: English
• ISSNs: 0008-6215

Abstract

Abstract: A series of novel, sugar or azasugar modified anthra[1, 2- d ] imidazole-6, 11-dione derivatives, with different side chain were synthesized, using the synthetic route of imidazole cyclization reaction of 1, 2-diaminoanthraquinone with various sugar (azasugar)-derived aldehydes, and imidazole cyclization reaction of 1, 2-diaminoanthraquinone with chloroacetic acid and then followed by the nucleophilic substitution of N -alkylamino azasugar. Their biological activities against HIV-RT and cytotoxic activities against A549, Hela and MCF-7 cells were preliminary evaluated, most compounds showed similar HIV-RT inhibition to the control drug (AZT). Graphical abstract: Highlights: Novel C -nucleoside analogues. Sugar or azasugar modified anthra[1, 2-d] imidazole-6, 11-dione derivatives. HIV-RT inhibition.