Cryptosporidium outbreak in calves on a large dairy farm: Effect of treatment and the association with the inflammatory response and short-term weight gain. (April 2018)

• Record Type: Journal Article
• Authors: Niine, Tarmo; Dorbek-Kolin, Elisabeth; Lassen, Brian; Orro, Toomas
• Is Part Of: Research in veterinary science. Volume 117(2018)
• Page Start: 200
• Page End: 208
• Publication Date: 2018-04
• Subjects: Calf morbidity -- Antiparasitic treatment -- Neonatal -- Gastrointestinal disorder -- Innate immunity response; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Médecine vétérinaire -- Recherche -- Périodiques; Diergeneeskunde; 636.089
• DOI: 10.1016/j.rvsc.2017.12.015
• Languages: English
• ISSNs: 0034-5288

Abstract

Abstract: Cryptosporidium spp. infections in neonatal dairy calves can cause diarrhoea and, in rare cases, death. The infection is usually self-limiting, but halofuginone lactate (HL) can be used prophylactically. Calves ( n = 144) in the study were born during a 2-month period on one farm. A total of 901 serum and 767 faecal samples were collected. Based on HL treatment, the calves were divided into 3 groups: I) not treated, II) treated incorrectly (treatment started > 48 h after birth, or lasted < 7 days), and III) treated correctly (started < 48 h after birth, and lasted ≥ 7 days). Over the 3-month observation period, 14.6% ( n = 21) of the calves died, of which most (67%) had not been treated with HL. Correctly performed treatment of cryptosporidiosis significantly delayed the onset of oocysts shedding ( P < 0.001) and reduced haptoglobin (HP) and serum amyloid A (SAA) concentrations in the second week of life. HP concentration and HL treatment were negatively associated with weight gain at 3 months of age. Cryptosporidium positive faecal samples were significantly ( P < 0.001) more likely to be diarrhoeic but Giardia or Eimeria positive samples were not. Correct prophylactic treatment with HL delayed the shedding of Cryptosporidium oocysts and improved survival, but was negatively associated with weight gain. Incorrect treatment had a low impact on mortality and resembled no treatment regarding the proportion of calves shedding oocysts. Acute phase response (APR) in the second week of life seemed to be positively associated with shedding high amounts of Cryptosporidium oocysts. Highlights: Acute phase response was affected by halofuginone lactate treatment. Haptoglobin concentration was more affected than serum amyloid A by Cryptosporidium . Gamma-glutamyltransferase activity after birth had a positive association with survival. Halofuginone lactate treatment had a negative effect on weight gain.