Fasting plasma glucose, oral glucose tolerance test, and the risk of first-time venous thromboembolism. A report from the VEINS cohort study. Issue 165 (May 2018)

• Record Type: Journal Article
• Authors: Johansson, Magdalena; Lind, Marcus; Jansson, Jan-Håkan; Fhärm, Eva; Johansson, Lars
• Is Part Of: Thrombosis research. Issue 165(2018)
• Page Start: 86
• Page End: 94
• Publication Date: 2018-05
• Subjects: 2HPG Oral glucose tolerance test two-hour post-load plasma glucose level -- CI Confidence interval -- CT Computed tomography -- DVT Deep vein thrombosis -- FPG Fasting plasma glucose -- HbA1c Glycated hemoglobin A -- HR Hazard ratio -- ICD International Classification of Diseases -- MRI Magnetic resonance imaging -- OGTT Oral glucose tolerance test -- SD Standard deviation -- VEINS Venous thromboEmbolism In Northern Sweden -- VIP Västerbotten Intervention Programme -- VTE Venous thromboembolism; Venous thromboembolism -- Venous thrombosis -- Pulmonary embolism -- Diabetes -- Glucose -- Glucose tolerance test; Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2018.03.015
• Languages: English
• ISSNs: 0049-3848

Abstract

Abstract: Introduction: It remains unclear whether high plasma glucose levels are associated with venous thromboembolism (VTE). This study investigated the association between fasting plasma glucose (FPG), oral glucose tolerance test (two-hour post-load plasma glucose (2HPG)), diabetes, and VTE. Materials and methods: The population-based, prospective Venous thromboEmbolism In Northern Sweden (VEINS) cohort study included 108, 025 residents of Västerbotten County in northern Sweden. The participants were aged 30 to 60 years and had no previous VTE events. They were included from 1985 onwards and were followed until a VTE event, death, emigration, or the study end on September 5, 2014. All underwent a health examination that measured weight, height, FPG, and 2HPG and included a questionnaire regarding smoking, education level, and history of diabetes. Potential VTE events were identified by an extensive diagnosis registry search and were validated by reviewing medical records and radiology reports. Results: An objectively verified first-time VTE event was experienced by 2054 participants during 1, 496, 669 person-years of follow-up. In univariable analysis, there were associations between FPG, 2HPG, diabetes, and the risk of VTE. These associations disappeared after adjustment for potential confounders (age, sex, body mass index, cancer at inclusion, education level, smoking, and hypertension). The adjusted hazard ratios were 1.01 (95% confidence interval 0.83–1.23) for diabetes, 1.01 for each standard deviation of FPG (95% confidence interval 0.97–1.05), and 0.96 for each standard deviation of 2HPG (95% confidence interval 0.91–1.00). Conclusions: There were no independent associations between FPG, 2HPG, diabetes, and future risk of VTE. Highlights: The association of glucose levels with venous thromboembolism (VTE) is unclear. This population-based cohort study included 108, 025 adults without VTE. Fasting plasma glucose and oral glucose tolerance tests were performed at inclusion. 2054 participants developed first-time VTE during 1.5 million person-years. There were no independent associations between glucose levels and VTE.