A Bayesian spatio-temporal framework to identify outbreaks and examine environmental and social risk factors for infectious diseases monitored by routine surveillance. (June 2018)

• Record Type: Journal Article
• Authors: Lal, Aparna; Marshall, Jonathan; Benschop, Jackie; Brock, Aleisha; Hales, Simon; Baker, Michael G; French, Nigel P
• Is Part Of: Spatial and spatio-temporal epidemiology. Volume 25(2018)
• Page Start: 39
• Page End: 48
• Publication Date: 2018-06
• Subjects: Spatial -- Temporal -- Surveillance -- Environmental -- Outbreaks -- Infections; Epidemiology -- Statistical methods -- Periodicals; Epidemiology -- Periodicals; 614.4072
• DOI: 10.1016/j.sste.2017.10.004
• Languages: English
• ISSNs: 1877-5845

Abstract

Highlights: A Bayesian spatio-temporal framework proposed to identify outbreaks and examine risk factors from routine surveillance data. This approach has detected previously unidentified disease clusters. The model also identified environmental risk factors associated with reported cryptosporidiosis and giardiasis. Abstract: Spatio-temporal disease patterns can provide clues to etiological pathways, but can be complex to model. Using a flexible Bayesian hierarchical framework, we identify previously undetected space-time clusters and environmental and socio-demographic risk factors for reported giardiasis and cryptosporidiosis at the New Zealand small area level. For giardiasis, there was no seasonal pattern in outbreak probability and an inverse association with density of dairy cattle ( β ^ 1 = −0.09, Incidence Risk Ratio (IRR) 0.90 (95% CI 0.84, 0.97) per 1 log increase in cattle/km 2 ). In dairy farming areas, cryptosporidiosis outbreaks were observed in spring. Reported cryptosporidiosis was positively associated with dairy cattle density: β ^ 1 = 0.12, IRR 1.13 (95% CI 1.05, 1.21) per 1 log increase in cattle/km 2 and inversely associated with weekly average temperature: β ^ 1 = −0.07, IRR 0.92 (95% CI 0.87, 0.98) per 4 °C increase. This framework can be generalized to determine the potential drivers of sporadic cases and latent outbreaks of infectious diseases of public health importance.