Small Lymph Node Metastasis Detected by 68Ga–Prostate-Specific Membrane Antigen But Not 18F-Fluciclovine PET/CT in Low–Prostate-Specific Antigen Biochemical Recurrence of Prostate Cancer. (April 2018)

• Record Type: Journal Article
• Authors: Chaussé, Guillaume; Abikhzer, Gad; Probst, Stephan
• Is Part Of: Clinical nuclear medicine. Volume 43:Number 4(2018)
• Publication Date: 2018-04
• Subjects: 18F-fluciclovine -- 68Ga-PSMA -- biochemical failure -- false negative -- metastasis -- PET/CT -- prostate cancer -- PSMA; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002009
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 58-year-old man with Gleason 4+3 prostate cancer was initially treated by radical prostatectomy followed by salvage radiotherapy to the prostate bed for postoperative biochemical failure. One year later, 18 F-fluorocholine PET/CT detected a pelvic lymph node recurrence, which was treated with radiation therapy and 6 months of androgen deprivation. PSA started to rise again 18 months later, but 18 F-fluciclovine PET/CT failed to demonstrate the site of recurrence at a PSA of 0.63 ng/mL. However, 68 Ga-PSMA PET/CT revealed a single positive 4-mm perirectal lymph node (PSA 0.80 ng/mL at time of scan), in retrospect anatomically apparent but negative on 18 F-fluciclovine PET/CT.