Measurement of pediatric regional cerebral blood flow from 6 months to 15 years of age in a clinical population. Issue 101 (April 2018)

• Record Type: Journal Article
• Authors: Carsin-Vu, Aline; Corouge, Isabelle; Commowick, Olivier; Bouzillé, Guillaume; Barillot, Christian; Ferré, Jean-Christophe; Proisy, Maia
• Is Part Of: European journal of radiology. Issue 101(2018)
• Page Start: 38
• Page End: 44
• Publication Date: 2018-04
• Subjects: (p)ASL (pulsed) arterial spin labeling -- MRI magnetic resonance imaging -- CBF cerebral blood flow -- GM gray matter -- WM white matter -- CSF cerebrospinal fluid -- ROIs regions of interest -- AAL automated anatomical labeling -- AIC Akaike's information criterion -- LRT likelihood ratio tests; Arterial spin labeling (ASL) -- Pediatric brain imaging -- Cerebral blood flow (CBF); Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2018.02.003
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: ASL technique is an innovative non-radiating and non-invasive method to quantify CBF. We provide ASL CBF values for GM and WM between 6 months and 15 years of age. GM CBF seems to increase up to 3–4 years of age and decline thereafter. There was no influence of gender and general anesthesia on CBF during childhood. Abstract: Objectives: To investigate changes in cerebral blood flow (CBF) in gray matter (GM) between 6 months and 15 years of age and to provide CBF values for the brain, GM, white matter (WM), hemispheres and lobes. Methods: Between 2013 and 2016, we retrospectively included all clinical MRI examinations with arterial spin labeling (ASL). We excluded subjects with a condition potentially affecting brain perfusion. For each subject, mean values of CBF in the brain, GM, WM, hemispheres and lobes were calculated. GM CBF was fitted using linear, quadratic and cubic polynomial regression against age. Regression models were compared with Akaike's information criterion (AIC), and Likelihood Ratio tests. Results: 84 children were included (44 females/40 males). Mean CBF values were 64.2 ± 13.8 mL/100 g/min in GM, and 29.3 ± 10.0 mL/100 g/min in WM. The best-fit model of brain perfusion was the cubic polynomial function (AIC = 672.7, versus respectively AIC = 673.9 and AIC = 674.1 with the linear negative function and the quadratic polynomial function). A statistically significant difference between the tested models demonstrating the superiority of the quadratic (p = 0.18) or cubic polynomial model (p = 0.06), over the negative linear regression model was not found. No effect of general anesthesia (p = 0.34) or of gender (p = 0.16) was found. Conclusion: we provided values for ASL CBF in the brain, GM, WM, hemispheres, and lobes over a wide pediatric age range, approximately showing inverted U-shaped changes in GM perfusion over the course of childhood.