Liver resection for colorectal cancer metastases: a comparison of outcomes over time in South Australia. Issue 4 (April 2018)

• Record Type: Journal Article
• Authors: Sultana, Asma; Meng, Rosie; Piantadosi, Cynthia; Brooke-Smith, Mark; Chen, John; Dolan, Paul; Maddern, Guy; Price, Timothy; Padbury, Robert
• Is Part Of: HPB. Volume 20:Issue 4(2018)
• Page Start: 340
• Page End: 346
• Publication Date: 2018-04
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 616.362005
• DOI: 10.1016/j.hpb.2017.10.005
• Languages: English
• ISSNs: 1365-182X

Abstract

Abstract: Background: The aim of the current study was to assess outcomes following liver resection in metastatic CRC (mCRC) in South Australia across two study periods (pre-2006 versus post-2006). Methods: The South Australian (SA) Clinical Registry for mCRC maintains data prospectively on all patients in SA with mCRC diagnosed from 01 February 2006. This data was linked with a prospectively collated database on liver resections for mCRC from 01/01/1992 to 01/02/2006. The primary end point was overall survival. Results: 757 patients underwent liver resection for mCRC. Liver resection was performed on 286 patients pre-2006 and 471 patients post-2006. The median age of the study population was 62 years, and this was similar across both eras. Overall survival was significantly better in the post-2006 era (hazard ratio HR = 0.45, p = 0.001). Complications (59% pre-2006 versus 23% post-2006) and transfusion rates (34% pre-2006 versus 2% post-2006) were significantly higher in the pre-2006 era. Repeat liver resection rates were significantly higher in the post-2006 era (1% pre-2006 versus 10% post-2006). Conclusions: Outcomes following liver resection for mCRC have improved over time, with significantly better overall survival in the post-2006 era compared to pre-2006.