In Vivo Dopamine Detection and Single Unit Recordings Using Intracortical Glassy Carbon Microelectrode Arrays. (23rd January 2018)

• Record Type: Journal Article
• Authors: Castagnola, Elisa; Winchester Vahidi, Nasim; Nimbalkar, Surabhi; Rudraraju, Srihita; Thielk, Marvin; Zucchini, Elena; Cea, Claudia; Carli, Stefano; Gentner, Timothy Q.; Ricci, Davide; Fadiga, Luciano; Kassegne, Sam
• Is Part Of: MRS advances. Volume 3:Number 29(2018)
• Page Start: 1629
• Page End: 1634
• Publication Date: 2018-01-23
• Subjects: sensor, -- devices, -- microelectronics; Electrical engineering -- Congresses; Physics -- Congresses; Materials -- Research -- Congresses; Materials science -- Congresses; 620.11
• DOI: 10.1557/adv.2018.98
• Languages: English
• ISSNs: 2059-8521

Abstract

ABSTRACT: In this study, we present a 4-channel intracortical glassy carbon (GC) microelectrode array on a flexible substrate for the simultaneous in vivo neural activity recording and dopamine (DA) concentration measurement at four different brain locations (220µm vertical spacing). The ability of GC microelectrodes to detect DA was firstly assessed in vitro in phosphate-buffered saline solution and then validated in vivo measuring spontaneous DA concentration in the Striatum of European Starling songbird through fast scan cyclic voltammetry(FSCV). The capability of GC microelectrode arrays and commercial penetrating metal microelectrode arrays to record neural activity from the Caudomedial Neostriatum of European starling songbird was compared. Preliminary results demonstrated the ability of GC microelectrodes in detecting neurotransmitters release and recording neural activity in vivo. GC microelectrodes array may, therefore, offer a new opportunity to understand the intimate relations linking electrophysiological parameters with neurotransmitters release.