MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?. Issue 5 (May 2018)

• Record Type: Journal Article
• Authors: Basu, Reetobrata; Qian, Yanrong; Kopchick, John J
• Is Part Of: European journal of endocrinology. Volume 178:Issue 5(2018)
• Page Start: R155
• Page End: R181
• Publication Date: 2018-05
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1530/EJE-18-0018
• Languages: English
• ISSNs: 0804-4643

Abstract

Abstract : Growth hormone (GH) is produced primarily by anterior pituitary somatotroph cells. Numerous acute human (h) GH treatment and long-term follow-up studies and extensive use of animal models of GH action have shaped the body of GH research over the past 70 years. Work on the GH receptor (R)-knockout (GHRKO) mice and results of studies on GH-resistant Laron Syndrome (LS) patients have helped define many physiological actions of GH including those dealing with metabolism, obesity, cancer, diabetes, cognition and aging/longevity. In this review, we have discussed several issues dealing with these biological effects of GH and attempt to answer the question of whether decreased GH action may be beneficial.