The risk of hypertension and cardiovascular disease in women with uterine fibroids. Issue 4 (22nd March 2018)

• Record Type: Journal Article
• Authors: Haan, Yentl C.; Diemer, Frederieke S.; Van Der Woude, Lisa; Van Montfrans, Gert A.; Oehlers, Glenn P.; Brewster, Lizzy M.
• Is Part Of: Journal of clinical hypertension. Volume 20:Issue 4(2018)
• Page Start: 718
• Page End: 726
• Publication Date: 2018-03-22
• Subjects: cardiovascular disease -- hypertension -- risk factors -- uterine fibroids -- women's health; Hypertension -- Periodicals; 616.132
• DOI: 10.1111/jch.13253
• Languages: English
• ISSNs: 1524-6175

Abstract

Abstract : Women with fibroids have a notably high hypertension risk. However, adjusted data regarding other cardiovascular disease (CVD) risk factors are scarce. In this cross‐sectional study, CVD risk factors, hemodynamic parameters, and asymptomatic organ damage were analyzed between women with uterine fibroids and controls in a multi‐ethnic population. In total, 104 women with self‐reported fibroids and 624 controls were included. Women with fibroids had significantly higher odds to have hypertension (OR 3.4; 95% CI 2.2‐5.2), diabetes (1.7; 1.0‐2.9), and hypercholesterolemia (1.8; 1.1‐3.2). After adjustment for confounders, only the odds ratio for hypertension was significant (1.8; 1.1‐3.1). Asymptomatic organ damage occurred significantly more often in women with fibroids (66.7%; 95% CI 55.8%‐77.6% vs 42.9%; 38.0‐47.8 in controls), especially in the younger age group (respectively 48.5%; 31.1%‐65.9% vs 22.1%; 17.0‐27.2). In this study, women with fibroids had a remarkably high hypertension risk compared to controls, with more asymptomatic organ damage, in particular young women.