Detection and genotyping of human papillomavirus (HPV) in HIV-infected women and its relationship with HPV/HIV co-infection. Issue 14 (April 2018)

• Record Type: Journal Article
• Authors: Badial, Rodolfo Miglioli; Dias, Marina Carrara; Stuqui, Bruna; Melli, Patrícia Pereira dos Santos; Quintana, Silvana Maria; Bonfim, Caroline Measso do; Cordeiro, José Antônio; Rabachini, Tatiana; Calmon, Marilia de Freitas; Provazzi, Paola Jocelan Scarin; Rahal, Paula
• Other Names: Shang. Liang section editor.
• Is Part Of: Medicine. Volume 97:Issue 14(2018)
• Publication Date: 2018-04
• Subjects: cervical lesions -- HIV -- HIV co-infection -- HPV; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000009545
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: HPV have been identified as high-risk and low-risk, depending on their association with the development of cancer. HPV infections can be facilitated by co-infection with HIV. Here, we investigated HPV prevalence and genotypes and the risk factors affecting HPV/HIV co-infection. Forty HIV-positive patients had 80 cervical swab samples collected in 2 consecutive years. Polymerase chain reaction and DNA direct sequencing were used to perform HPV genotyping. Statistical analyses were performed regarding risk factors for HPV/HIV co-infection and the occurrence of cervical lesions. HPV DNA was detected in 59 samples (73.75%), and high-risk HPVs were predominant (59.3%). The most prevalent type was HPV56 (17%), followed by HPV16 (15.3%). Patient age did not affect the risk of cervical cancer ( P = .84) or HPV prevalence in different years ( P = .25/ P = .63). CD4 count also did not affect the risk for cervical lesions in the tested samples ( P = .15/ P = .28). Although the HIV viral load was not correlated with an increase in cervical lesion detection in the first group of analyzed samples ( P = .12), it did affect cervical cancer risk in the group of samples analyzed in the following year ( P = .045). HIV-infected patients presented a high prevalence of HPV co-infection, and HPV16 and HPV56 were the most prevalent genotypes. Considering this, it is possible that immunodeficiency can contribute to increased susceptibility to HPV56 infection in HIV-infected patients. The association between HIV viral load and the lesions also confirmed the importance of monitoring HIV/HPV co-infected patients with high HIV viral loads.