Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression. (10th July 2018)

• Record Type: Journal Article
• Authors: Sang, Meixiang; Meng, Lingjiao; Sang, Yang; Liu, Shina; Ding, Pingan; Ju, Yingchao; Liu, Fei; Gu, Lina; Lian, Yishui; Li, Juan; Wu, Yunyan; Zhang, Xiaochong; Shan, Baoen
• Is Part Of: Cancer letters. Volume 426(2018)
• Page Start: 37
• Page End: 46
• Publication Date: 2018-07-10
• Subjects: ESCC -- Circular RNA -- ciRS-7 -- miR-876-5p -- MAGE-A; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2018.03.049
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: As the most well-known circular RNA, ciRS-7 (also termed CDR1as) has been reported to act as a miR-7 sponge, resulting in reduced miR-7 activity and increased miR-7-targeted transcripts. Here, we showed that ciRS-7 is up-regulated in esophageal squamous cell carcinoma (ESCC), and is associated with the poor clinicopathological parameters of ESCC patients. Moreover, over-expression of ciRS-7 increased the proliferation, migration and invasion of ESCC cells. Mechanistic studies revealed that ciRS-7 contains nineteen miR-876-5p binding sites and acts as a miR-876-5p sponge. Over-expression of ciRS-7 resulted in the reduced tumor-repressive function of miR-876-5p on its downstream target MAGE-A family. In animal experiments, enforced ciRS-7 increased ESCC tumor growth and metastasis through targeting miR-876-5p/MAGE-A family axis. Collectively, our study provided novel evidence that ciRS-7 accelerates ESCC progression by acting as a miR-876-5p sponge to enhance MAGE-A family expression. Highlights: Circular RNA ciRS-7 is highly expressed in ESCC. Over-expression of ciRS-7 increases the proliferation, migration and invasion of ESCC cells. Circular RNA ciRS-7 acts as a sponge of miR-876-5p in ESCC. Circular RNA ciRS-7 inhibits tumor-repressive function of miR-876-5p on its downstream target MAGE-A family. Enforced ciRS-7 increased ESCC tumor growth and metastasis through targeting miR-876-5p/MAGE-A family axis.