Labral calcification in end‐stage osteoarthritis of the hip correlates with pain and clinical function. Issue 4 (9th October 2017)

• Record Type: Journal Article
• Authors: Hubert, Jan; Hawellek, Thelonius; Moe, Martin; Hischke, Sandra; Krause, Matthias; Rolvien, Tim; Schmidt, Tobias; Rüther, Wolfgang; Niemeier, Andreas
• Is Part Of: Journal of orthopaedic research. Volume 36:Issue 4(2018)
• Page Start: 1248
• Page End: 1255
• Publication Date: 2017-10-09
• Subjects: cartilage calcification -- hip -- labrum -- pain -- osteoarthritis; Orthopedics -- Periodicals; Musculoskeletal system -- Periodicals; 616.7
• DOI: 10.1002/jor.23736
• Languages: English
• ISSNs: 0736-0266

Abstract

ABSTRACT: The acetabular labrum of the hip (ALH) is recognized as a clinically important structure, but knowledge about the pathophysiology of this fibrocartilage is scarce. In this prospective study we determined the prevalence of ALH calcification in patients with end‐stage osteoarthritis (OA) and analyzed the relationship of cartilage calcification (CC) with hip pain and clinical function. Cohort of 80 patients (70.2 ± 7.6years) with primary OA scheduled for total hip replacement. Harris Hip Score (HHS) was recorded preoperatively. Total ALH and femoral head (FH) were sampled intraoperatively. CC of the ALH and FH was analyzed by high‐resolution digital contact radiography. Histological degeneration of the ALH (Krenn‐Score) and FH (OARSI‐Score) was determined. Multivariate linear regression model and partial correlation analyses were performed. The prevalence of cartilage calcification both in the ALH and FH was 100%, while the amount of CC in the ALH was 1.55 times higher than in the FH ( p < 0.001). There was a significant inverse regression between the amount of calcification of both the ALH and the FH and preoperative HHS ( β ALH = −2.1, p = 0.04), ( β FH = −2.9, p = 0.005), but pain was influenced only by ALH calcification ( β ALH = −2.7, p = 0.008). Age‐adjusted, there was a significant correlation between cartilage calcification and histological degeneration (ALH:rs = 0.53, p < 0.001/FH: r s = 0.30, p = 0.007). Fibrocartilage and articular cartilage calcification are inseparable pathological findings in end‐stage osteoarthritis of the hip. Fibrocartilage calcification is associated with poor and painful hip function. Clinical significance: ALH fibrocartilage appears to be particularly prone to calcification, which may explain higher pain levels in individuals with a high degree of ALH calcification independent of age and histological degeneration. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1248–1255, 2018. Abstract : The prevalence of cartilage calcification (CC) both in the acetabular labrum (ALH) and the femoral head (FH) was 100% and correlated with cartilage degeneration, clinical OA severity and declining hip function. The amount of ALH CC was 1.55 times higher and pain was influenced only by ALH calcification. This study identifies the ALH as a key tissue in CC of the osteoarthritic hip and ALH calcification as a possible player in mediating otherwise unexplained differences in pain levels in hip‐OA.