Ni‐Catalyzed C−F Bond Functionalization of Unactivated Aryl Fluorides and Corresponding Coupling with Oxazoles. Issue 8 (9th March 2018)

• Record Type: Journal Article
• Authors: Yin, Youzhi; Yue, Xiaoyu; Zhong, Qi; Jiang, Hanmin; Bai, Ruopeng; Lan, Yu; Zhang, Hua
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 8(2018)
• Page Start: 1639
• Page End: 1643
• Publication Date: 2018-03-09
• Subjects: nickel catalysis -- C−F functionalization -- C−H functionalization -- oxazoles -- cross-coupling; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201701506
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A Ni‐catalyzed C−F bond functionalization of unactivated aryl fluorides with oxazoles as coupling partners was developed. Various arylated oxazoles could be obtained in moderate to good yields in the presence of Ni(cod)2 /IMes catalytic system. A rapid synthesis of natural product texaline was also demonstrated using this protocol. This transformation could be potentially utilized in regioselective introduction of an oxazole group in late‐stage synthetic applications. Abstract :