Electrohysterographic characterization of the uterine myoelectrical response to labor induction drugs. (June 2018)

• Record Type: Journal Article
• Authors: Benalcazar-Parra, Carlos; Ye-Lin, Yiyao; Garcia-Casado, Javier; Monfort-Orti, Rogelio; Alberola-Rubio, Jose; Perales, Alfredo; Prats-Boluda, Gema
• Is Part Of: Medical engineering & physics. Volume 56(2018)
• Page Start: 27
• Page End: 35
• Publication Date: 2018-06
• Subjects: Labor induction -- Cervical ripening -- Drug effects -- Surface electromyography -- Electrohysterography -- Signal processing -- Computer-assisted signal interpretation; Biomedical engineering -- Periodicals; Biomedical Engineering -- Periodicals; Physics -- Periodicals; Génie biomédical -- Périodiques; Biomedical engineering; Electronic journals; Periodicals; 610.28
• DOI: 10.1016/j.medengphy.2018.04.002
• Languages: English
• ISSNs: 1350-4533

Abstract

Highlights: We characterize the uterine myoelectrical response to labor induction drugs. We compute a set of parameters extracted from electrohysterography records. Successful labor induction is associated to an increment in amplitude and/or frequency. EHG features are able to discriminate success and failure groups in women induced with misoprostol. EHG affords valuable information of the uterine myoelectrical state during induction. Abstract: Labor induction is a common practice to promote uterine contractions and labor onset. Uterine electrohysterogram (EHG) has proved its suitability for characterizing the uterus electrophysiological condition in women with spontaneous labor. The aim of this study was to characterize and compare uterine myoelectrical activity during the first 4 h in response to labor induction drugs, Misoprostol (G1) and Dinoprostone (G2), by analyzing the differences between women who achieved active phase of labor and those who did not (successful and failed inductions). A set of temporal, spectral and complexity parameters were computed from the EHG-bursts. As for successful inductions, statistical significant and sustained increases with respect to basal period were obtained for EHG amplitude, mean frequency, uterine activity index (UAI) and Teager, after 60′ for the G1 group; duration, amplitude, number of contractions and UAI for the G2 group, after 120′. Moreover, Teager showed statistical significant and sustained differences between successful and failed inductions (1.43 ± 1.45 µV 2. Hz 2. 10 5 vs. 0.40 ± 0.26 µV 2. Hz 2. 10 5 after 240′) for the G1 group, but not in the G2 group, probably due to the slower pharmacokinetics of this drug. These results revealed that EHG could be useful for successful induction prediction in the early stages of induction, especially when using Misoprostol.