Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population. (June 2015)

• Record Type: Journal Article
• Authors: Jia, Shasha; Dong, Wanli; Zhou, Xianju; Chen, Zhiguo; Yun, Wenwei
• Is Part Of: Journal of international medical research. Volume 43:Number 3(2015:Jun.)
• Page Start: 326
• Page End: 331
• Publication Date: 2015-06
• Subjects: Migraine -- TNFSF10 -- gene polymorphisms -- susceptibility; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060514565681
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10 . Methods: Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis. Results: Rs35975099 was in Harvey–Weinberg equilibrium in patients with migraine ( n = 269) and control subjects ( n = 374). There were no significant relationships between allele or genotype frequency and migraine. Conclusion: There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis.