Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents. (April 2018)

• Record Type: Journal Article
• Authors: Jiang, Hao-Wen; Lin, Jing; Wang, Gui-Min; Zhang, Jing-Jing; Gu, Shan-Shan; Cao, Lei; Chen, Yan; Wang, Ling; Jiao, He; Zhu, Wei-Liang; Zhang, Hai-Yan; Zhao, Wei-Min; Li, Jin-Long
• Is Part Of: Phytochemistry letters. Volume 24(2018)
• Page Start: 179
• Page End: 183
• Publication Date: 2018-04
• Subjects: Cynanchum wilfordii -- Acetophenone derivatives -- Aβ aggregation -- Neuroprotective; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2018.02.002
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Seven new acetophenones were isolated form Cynanchum wilfordii (Maxim.) Hemsl. Each racemate was separated into individual enantiomers by chiral HPLC. ECD calculations were used to assign the enantiomers' absolute configurations. (+)-3 and (−)-3 showed neuroprotective effects on Aβ-treated SH-SY5Y cells. Abstract: Seven new acetophenone derivatives, three couples of enantiomers (±)-cynwilforones D − F (1 − 3 ) together with cynwilforone G (4 ), were isolated form the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and X-ray crystallography. Each racemate was separated into individual enantiomers, and electronic circular dichroism (ECD) calculations were used to assign their absolute configurations. All compounds exhibited inhibitory effect of A β oligomerization in different degrees. Among them, (+)-3 and (− )-3 showed neuroprotective effects on A β oligomers-treated SH-SY5Y cells.