Utility of DNA methylation to assess placental health. (April 2018)

• Record Type: Journal Article
• Authors: Wilson, Samantha L.; Robinson, Wendy P.
• Is Part Of: Placenta. Volume 64(2018)Supplement 1
• Page Start: S23
• Page End: S28
• Publication Date: 2018-04
• Subjects: DNA methylation -- Epigenetic wide association studies -- Reproducibility -- Placental insufficiency -- Cell type composition -- Preeclampsia -- Intrauterine growth restriction; PE Preeclampsia -- IUGR Intrauterine growth restriction -- EOPE early onset preeclampsia -- LOPE late onset preeclampsia -- DNAm DNA methylation -- CpG cytosine-phosphate-guanosine -- PGCs primordial germ cells -- PMD partially methylated domains -- mQTL Methylation quantitative trait loci -- SNPs single nucleotide polymorphisms -- DoHAD developmental origins of health a disease -- EWAS epigenetic-wide association studies; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2017.12.013
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: DNA methylation (DNAm), a mitotically stable epigenetic mark, can influence as well as reflect gene expression. DNAm has been gaining interest for use as a biomarker for many conditions including placental insufficiency, specifically preeclampsia (PE) and intrauterine growth restriction (IUGR). Additionally, DNAm may retain a "memory" of earlier in utero exposures and hence provide insight into pathogeneses occurring earlier in gestation. This review will discuss the placental DNA methylome, the uses of DNAm to assess placental health, and considerations and limitations to understand in epigenome-wide association studies (EWAS).