Bioactive hydroanthraquinones from endophytic fungus Nigrospora sp. BCC 47789. (April 2018)

• Record Type: Journal Article
• Authors: Kornsakulkarn, Jittra; Choowong, Wilunda; Rachtawee, Pranee; Boonyuen, Nattawut; Kongthong, Surisa; Isaka, Masahiko; Thongpanchang, Chawanee
• Is Part Of: Phytochemistry letters. Volume 24(2018)
• Page Start: 46
• Page End: 50
• Publication Date: 2018-04
• Subjects: Hydroanthraquinone -- Endophytic fungus -- Nigrospora sp. -- Bioactive secondary metabolites; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2018.01.015
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: The constituents of endophytic fungus Nigrospora sp. BCC 47789 were investigated. A new nigrosporone A and a new naturally occurring nigrosporone B were isolated. The absolute configurations of nigrosporones A and B were also established. Nigrosporone B exhibited broad range of biological activities. Nigrosporone A and fusaquinon A showed only cytotoxic activity. Abstract: A new hydroanthraquinone, nigrosporone A (1), and a new naturally occurring nigrosporone B (2 ), together with eleven known compounds, were isolated from an endophytic fungus, Nigrospora sp. BCC 47789. The structure of nigrosporone A was confirmed by X-ray crystallographic analysis. The absolute configurations of nigrosporone B were determined by the modified Mosher's method. Nigrosporone B exhibited a broad range of biological activities including antimalarial, antitubercular, antibacterial and cytotoxic activities, while nigrosporone A and Fusaquinon A showed only cytotoxic activity.