Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis. (May 2018)

• Record Type: Journal Article
• Authors: Majdinasab, Nastaran; Motl, Robert W.; Mokhtarzade, Motahare; Zimmer, Philipp; Ranjbar, Rouholah; Keytsman, Charly; Cullen, Tom; Negaresh, Raoof; Baker, Julien S.
• Is Part Of: Complementary therapies in clinical practice. Volume 31(2018)
• Page Start: 295
• Page End: 301
• Publication Date: 2018-05
• Subjects: Multiple sclerosis -- Cytokines -- Inflammation -- Adipokines -- Aerobic interval exercise; Integrative medicine -- Periodicals; Integrative medicine -- Research -- Periodicals; Alternative medicine -- Periodicals; 615.5
• DOI: 10.1016/j.ctcp.2018.03.004
• Languages: English
• ISSNs: 1744-3881

Abstract

Abstract: Objective: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS). Methods: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60–70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise. Results: Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups. Conclusion: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance. Highlights: Exercise does not influence the inflammatory response of the cytokine profile. Exercise temporarily improves cytokine and adipokine balance in the relapsing phase of multiple sclerosis. Exercise successfully influences leptin in relapses of multiple sclerosis. Exercise seems safe, tolerable and feasible following relapse in multiple sclerosis patients.