Transformation of a Primitive Myxoid Mesenchymal Tumor of Infancy to an Undifferentiated Sarcoma: A First Reported Case. Issue 2 (March 2015)

• Record Type: Journal Article
• Authors: Guilbert, Marie-Christine; Rougemont, Anne-Laure; Samson, Yvan; Mac-Thiong, Jean-Marc; Fournet, Jean-Christophe; Soglio, Dorothee Bouron-Dal
• Is Part Of: Journal of pediatric hematology/oncology. Volume 37:Issue 2(2015)
• Publication Date: 2015-03
• Subjects: pediatric tumor -- head and neck -- PMMTI -- undifferentiated high-grade sarcoma; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000000107
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : An 8-month-old girl underwent surgical resection of a cervical mass with histologic diagnosis of a primitive myxoid mesenchymal tumor of infancy (PMMTI). More than 5 years after the initial surgical intervention, the tumor recurred locally, with numerous distant metastases. The histologic morphology of this tumor was compatible with a diagnosis of an undifferentiated high-grade sarcoma. PMMTI is a recently described poorly differentiated fibroblastic soft-tissue tumor of infancy, of at least borderline biological behavior, characterized by local recurrence and a potential to metastasize. We present here the first case of a transformation of a PMMTI into an undifferentiated high-grade sarcoma.