Relationship Between Female Hormonal and Menstrual Factors and Pancreatic Cancer: A Meta-Analysis of Observational Studies. Issue 7 (February 2015)

• Record Type: Journal Article
• Authors: Tang, Bo; Lv, Jiannan; Li, Yang; Yuan, Shengguang; Wang, Zhenran; He, Songqing
• Other Names: Burke. Harry section editor.
• Is Part Of: Medicine. Volume 94:Issue 7(2015)
• Publication Date: 2015-02
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000000177
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: The objective of this study was to assess the relationship between female hormone and menstrual factors and pancreatic cancer (PC) through a meta-analysis of observational studies. We undertook a systematic literature search up to July 10, 2014 in PubMed and EMBASE databases. Combined relative risks (RRs) were estimated by random-effects models. Subgroup analysis was performed by study design, source of control, and geographic regions. Sensitivity analyses and publication bias were utilized to evaluate the robustness of our results. A total of 27 case–control and cohort studies were retrieved for this meta-analysis. No significant associations were observed between the risk of PC and age at menarche (RR = 0.94, 95% confidence interval [CI] 0.83–1.07), age at menopause (RR = 0.98, 95% CI 0.85–1.13), hysterectomy (RR = 0.97, 95% CI 0.84–1.11), oophorectomy (RR = 1.02, 95% CI 0.82–1.26), hormone replacement therapy (RR = 0.97, 95% CI 0.87–1.08), and oral contraceptives (RR = 1.09, 95% CI 0.96–1.23). This meta-analysis of observational studies does not support the hypothesis that exogenous hormone use and menstrual factors are associated with PC.