Molecular characterization and multidisciplinary management of Gerbich hemolytic disease of the newborn. Issue 6 (22nd February 2018)

• Record Type: Journal Article
• Authors: Levitt, Rebecca N.; Gourri, Elise; Gassner, Christoph; Banez‐Sese, Grace; Salam, Abdus; Denomme, Gregory A.; Yang, Elizabeth
• Is Part Of: Pediatric blood & cancer. Volume 65:Issue 6(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-02-22
• Subjects: anti‐Ge3 -- Ge -- Gerbich -- GYPC -- HDFN -- HDN -- hemolytic disease of the fetus and newborn -- maternal alloimmunization -- maternal blood transfusion; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.27014
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Gerbich (Ge) antigens are high frequency red cell antigens expressed on glycophorin C (GYPC) and glycophorin D. Hemolytic disease of the fetus and newborn (HDFN) due to Gerbich antibody is rare and presents a clinical challenge, as Gerbich negative blood is scarce. We report a case of HDFN due to maternal Ge3 negative phenotype and anti‐Ge3 alloimmunization, successfully managed by transfusion of maternal blood. Molecular testing revealed that the mother has homozygous deletion of exon 3 of GYPC, the father is homozygous wildtype for GYPC, and the infant is obligate heterozygote expressing Ge3.