Risk factors for salivary gland cancers in France: Results from a case-control study, the ICARE study. (May 2018)

• Record Type: Journal Article
• Authors: Radoï, Loredana; Barul, Christine; Menvielle, Gwenn; Carton, Matthieu; Matrat, Mireille; Sanchez, Marie; Pilorget, Corinne; Velten, Michel; Stücker, Isabelle; Luce, Danièle
• Is Part Of: Oral oncology. Volume 80(2018)
• Page Start: 56
• Page End: 63
• Publication Date: 2018-05
• Subjects: Salivary gland neoplasms -- Head and neck cancers -- Occupations -- Industry -- Epidemiologic studies -- Risk factors -- Life style; SGC salivary gland cancers -- HNC head and neck cancers -- BMI body mass index -- ICARE Investigation of occupational and environmental causes of respiratory cancers -- JEM job-exposure matrices -- ISCO International Standard Classification of Occupations -- NAF French Nomenclature of Activities -- CEI cumulative exposure index -- OR odds ratio -- CI confidence interval; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2018.03.019
• Languages: English
• ISSNs: 1368-8375

Abstract

Highlights: Tobacco and alcohol consumption did not increase the risk of salivary gland cancer. History of head and neck cancer and cervicofacial radiotherapy increased the risk. Several occupations and industries were associated with elevated risks. Statistical power was limited for in-depth analyses. Abstract: Objectives: Epidemiological studies on the risk factors for salivary gland cancers (SGC) are rare, concern a small sample size, and show inconsistent results. The aim of the present work was to analyze several risk factors for SGC, using the data from the ICARE study, a multicenter, population-based case-control study. Materials and methods: Data from 73 SGC cases and 3555 controls were collected using a standardized questionnaire on lifestyle habits, personal and family medical history, and lifetime occupational history. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regressions. Results: Tobacco use and alcohol consumption were not associated with the risk of SGC. A history of head and neck cancer or that of cervicofacial radiotherapy was associated with a higher risk of SGC (OR = 17.06, 95% CI: 4.34–67.05, and OR = 31.74, 2.48–405.25, respectively). Significantly increased risks were observed for some occupations: waiter (OR = 2.94, 1.11–7.78), charworker (OR = 3.02, 1.38–6.60), electrical and electronic equipment assembler (OR = 7.16, 2.02–25.38), plumber (OR = 3.95, 1.33–11.67), electric arc welder (OR = 6.15, 1.76–21.48), sheet-metal worker (OR = 2.89, 1.01–8.32), building painter (OR = 3.42, 1.01–11.49), and material handling equipment operator (OR = 5.05, 1.71–14.84). Results for industries were consistent with those observed for occupations. Conclusion: Our results showed that a history of head and neck cancer, cervicofacial radiotherapy, and several occupations and industries, were associated with an increased risk of SGC. Further studies with larger sample sizes are indicated to confirm our results.