A Novel Theranostic Nanoplatform Based on Pd@Pt‐PEG‐Ce6 for Enhanced Photodynamic Therapy by Modulating Tumor Hypoxia Microenvironment. (26th February 2018)

• Record Type: Journal Article
• Authors: Wei, Jingping; Li, Jingchao; Sun, Duo; Li, Qi; Ma, Jinyuan; Chen, Xiaolan; Zhu, Xuan; Zheng, Nanfeng
• Is Part Of: Advanced functional materials. Volume 28:Number 17(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-02-26
• Subjects: enhanced photodynamic therapy -- fluorescence imaging -- hypoxia modulation -- Pd@Pt‐PEG‐Ce6 nanocomposites; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201706310
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Photodynamic therapy (PDT), which utilizes reactive oxygen species to kill cancer cells, has found wide applications in cancer treatment. However, the hypoxic nature of most solid tumors can severely restrict the efficiency of PDT. Meanwhile, the hydrophobicity and limited tumor selectivity of some photosensitizers also reduce their PDT efficacy. Herein, a photosensitizer‐Pd@Pt nanosystem (Pd@Pt‐PEG‐Ce6) is designed for highly efficient PDT by overcoming these limitations. In the nanofabrication, Pd@Pt nanoplates, exhibiting catalase‐like activity to decompose H2 O2 to generate oxygen, are first modified with bifunctional PEG (SH‐PEG‐NH2 ). Then the Pd@Pt‐PEG is further covalently conjugated with the photosensitizer chlorin e6 (Ce6) to get Pd@Pt‐PEG‐Ce6 nanocomposite. The Pd@Pt‐PEG‐Ce6 exhibits good biocompatibility, long blood circulation half‐life, efficient tumor accumulation, and outstanding imaging properties. Both in vitro and in vivo experimental results clearly indicate that Pd@Pt‐PEG‐Ce6 effectively delivers photosensitizers to cancer cells/tumor sites and triggers the decomposition of endogenous H2 O2 to produce oxygen, resulting in a remarkably enhanced PDT efficacy. Moreover, the moderate photothermal effect of Pd@Pt nanoplates also strengthen the PDT of Pd@Pt‐PEG‐Ce6. Therefore, by integrating the merits of high tumor‐specific accumulation, hypoxia modulation function, and mild photothermal effect into a single nanoagent, Pd@Pt‐PEG‐Ce6 readily acts as an ideal nanotherapeutic platform for enhanced cancer PDT. Abstract : In this work, a Pd‐based theranostic nanoplatform (Pd@Pt‐PEG‐Ce6) with manifold merits is successfully fabricated and applied to photodynamic therapy (PDT) against hypoxia tumor. By utilizing its catalase‐like activity, high tumor accumulation, and mild photothermal effect to modulate and improve the O2 level in hypoxia tumor microenvironment, the PDT efficacy based on Pd@Pt‐PEG‐Ce6 is greatly enhanced.