Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives. Issue 3 (19th January 2018)

• Record Type: Journal Article
• Authors: Xiao, Sulong; Tian, Zhenyu; Wang, Yufei; Si, Longlong; Zhang, Lihe; Zhou, Demin
• Editors: Tang, Xinjing; Wang, Shaoru
• Is Part Of: Medicinal research reviews. Volume 38:Issue 3(2018)
• Page Start: 951
• Page End: 976
• Publication Date: 2018-01-19
• Subjects: antiviral -- betulinic acid -- glycyrrhizin -- mechanism -- pentacyclic triterpenoid; Pharmacology -- Periodicals; Drugs -- Research -- Periodicals; 615
• DOI: 10.1002/med.21484
• Languages: English
• ISSNs: 0198-6325

Abstract

Abstract: Viral infections cause many serious human diseases with high mortality rates. New drug‐resistant strains are continually emerging due to the high viral mutation rate, which makes it necessary to develop new antiviral agents. Compounds of plant origin are particularly interesting. The pentacyclic triterpenoids (PTs) are a diverse class of natural products from plants composed of three terpene units. They exhibit antitumor, anti‐inflammatory, and antiviral activities. Oleanolic, betulinic, and ursolic acids are representative PTs widely present in nature with a broad antiviral spectrum. This review focuses on the recent literatures in the antiviral efficacy of this class of phytochemicals and their derivatives. In addition, their modes of action are also summarized.