In chronic lymphocytic leukaemia with complex karyotype, major structural abnormalities identify a subset of patients with inferior outcome and distinct biological characteristics. (2nd April 2018)

• Record Type: Journal Article
• Authors: Rigolin, Gian Matteo; Saccenti, Elena; Guardalben, Emanuele; Cavallari, Maurizio; Formigaro, Luca; Zagatti, Barbara; Visentin, Andrea; Mauro, Francesca R.; Lista, Enrico; Bassi, Cristian; Lupini, Laura; Quaglia, Francesca Maria; Urso, Antonio; Bardi, Maria Antonella; Bonaldi, Laura; Volta, Eleonora; Tammiso, Elisa; Ilari, Caterina; Cafforio, Luciana; Melandri, Aurora; Cavazzini, Francesco; Negrini, Massimo; Semenzato, Gianpietro; Trentin, Livio; Foà, Robin; Cuneo, Antonio
• Is Part Of: British journal of haematology. Volume 181:Number 2(2018)
• Page Start: 229
• Page End: 233
• Publication Date: 2018-04-02
• Subjects: chronic lymphocytic leukaemia -- complex karyotype -- gene expression profile -- overall survival -- time to first treatment; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.15174
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: Complex karyotype (CK) is a negative prognostic factor in chronic lymphocytic leukaemia (CLL). However, CK is a heterogeneous cytogenetic category. Unbalanced rearrangements were present in 73·3% of 90 CLL patients with CK (i.e. ≥3 chromosome aberrations in the same clone), and were associated with a shorter overall survival ( P = 0·025) and a shorter time to first treatment ( P = 0·043) by multivariate analysis. Patients with unbalanced rearrangements presented a distinct mRNA expression profile. In conclusion, CLL patients with unbalanced rearrangements might represent a subset of very high‐risk CLL patients with distinct clinical and biological characteristics.