Identification of novel translocation between short arm of chromosome 4 and long arm of chromosome 6 in an infertile man using Interphase Chromosome Profiling (ICP). (7th February 2018)

• Record Type: Journal Article
• Authors: Kaul, S.; Kaur, H.; Vats, S.K.S.; Chawla, J.; Jindal, R.; Khetarpal, P.
• Is Part Of: Andrologia. Volume 50:Number 4(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-02-07
• Subjects: chromosome translocation -- infertility -- interphase chromsome profiling; Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.12954
• Languages: English
• ISSNs: 0303-4569

Abstract

Summary: Conventional cytogenetics has always been a favourite to detect chromosomal aberrations. Carriers of chromosomal translocation are often phenotypically normal but are infertile. Couples are often advised to go for karyotyping, but culture failure or improper metaphase spread with poor banding often makes the analysis difficult. We report here a novel translocation between short arm of chromosome 4 and long arm of chromosome 6 in an infertile man using an advanced molecular cytogenetic technique of Interphase Chromosome Profiling (ICP).