Facile meltPEGylation of flame-made luminescent Tb3+-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica. Issue 23 (2nd March 2018)

• Record Type: Journal Article
• Authors: Keevend, Kerda; Panzarasa, Guido; Starsich, Fabian H. L.; Zeltner, Martin; Spyrogianni, Anastasia; Tsolaki, Elena; Fortunato, Giuseppino; Pratsinis, Sotiris E.; Bertazzo, Sergio; Herrmann, Inge K.
• Is Part Of: Chemical communications. Volume 54:Issue 23(2018)
• Page Start: 2914
• Page End: 2917
• Publication Date: 2018-03-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc09402g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : MeltPEGylation constitutes an elegant one-pot route for the efficient PEGylation of metal oxide nanoparticles with improved hemo- and cytocompatibility. Abstract : Flame aerosol technology is a versatile method for scalable synthesis of nanoparticles. Since particles are produced and collected in a dry state, dispersibility and further functionalization could pose hurdles to their biomedical use. We report on a one-pot, scalable and robust procedure for the PEGylation of flame-made yttria and silica nanoparticles. We demonstrate improved colloidal stability, attenuated activation of blood coagulation and decreased uptake into phagocytic cells, all of which pave the way for facilitated biomedical use of flame-made oxide nanoparticles.