Effect of a nitric oxide donor on maternal hemodynamics in fetal growth restriction. (10th April 2018)

• Record Type: Journal Article
• Authors: Tiralongo, G. M.; Pisani, I.; Vasapollo, B.; Khalil, A.; Thilaganathan, B.; Valensise, H.
• Is Part Of: Ultrasound in obstetrics & gynecology. Volume 51:Number 4(2018)
• Page Start: 514
• Page End: 518
• Publication Date: 2018-04-10
• Subjects: fetal growth restriction -- FGR -- maternal hemodynamics -- nitric oxide donor -- NO donor -- total vascular resistance -- TVR -- UltraSonic Cardiac Output Monitor -- USCOM; Ultrasonics in obstetrics -- Periodicals; Generative organs, Female -- Diseases -- Diagnosis -- Periodicals; Diagnosis, Ultrasonic -- Periodicals; Genital Diseases, Female -- ultrasonography -- Periodicals; Ultrasonography, Prenatal -- Periodicals; 618.047543
• DOI: 10.1002/uog.17454
• Languages: English
• ISSNs: 0960-7692

Abstract

ABSTRACT: Objective: To evaluate the effect on maternal cardiovascular parameters of treatment with a nitric oxide (NO) donor and plasma volume expansion in pregnancies complicated by fetal growth restriction (FGR). Methods: Twenty‐six pregnant women with a diagnosis of FGR were treated with transdermal patches of a NO donor and plasma volume expansion by co‐administration of oral fluids. We compared the treated group to a historical control group of untreated FGR patients. Hemodynamic indices were obtained using the UltraSonic Cardiac Output Monitor system. Results: At diagnosis, the two groups were similar in terms of maternal and hemodynamic characteristics. In the treated group, we found a significant increase in maternal cardiac output and stroke volume and a decrease in systemic vascular resistance after 2 weeks of therapy. No significant differences were found 2 weeks after diagnosis in the untreated group. The treated group delivered infants with higher birth‐weight centile than did the untreated control group. Conclusions: The combined therapeutic approach of NO donor administration and plasma volume expansion in FGR apparently improves significantly maternal hemodynamic indices. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.