Mice with cancer-induced bone pain show a marked decline in day/night activity. (September 2017)

• Record Type: Journal Article
• Authors: Majuta, Lisa A.; Guedon, Jean-Marc G.; Mitchell, Stefanie A.T.; Kuskowski, Michael A.; Mantyh, Patrick W.
• Is Part Of: Pain reports. Volume 2:Number 5(2017)
• Publication Date: 2017-09
• Subjects: Bone -- Pain -- CIBP -- Functional status -- Activity -- Day/night activity
• DOI: 10.1097/PR9.0000000000000614
• Languages: English
• ISSNs: 2471-2531

Abstract

Abstract: Introduction: Cancer-induced bone pain (CIBP) is the most common type of pain with cancer. In humans, this pain can be difficult to control and highly disabling. A major problem with CIBP in humans is that it increases on weight-bearing and/or movement of a tumor-bearing bone limiting the activity and functional status of the patient. Currently, there is less data concerning whether similar negative changes in activity occur in rodent models of CIBP. Objectives: To determine whether there are marked changes in activity in a rodent model of CIBP and compare this to changes in skin hypersensitivity. Methods: Osteosarcoma cells were injected and confined to 1 femur of the adult male mouse. Every 7 days, spontaneous horizontal and vertical activities were assessed over a 20-hour day and night period using automated activity boxes. Mechanical hypersensitivity of the hind paw skin was assessed using von Frey testing. Results: As the tumor cells grew within the femur, there was a significant decline in horizontal and vertical activity during the times of the day/night when the mice are normally most active. Mice also developed significant hypersensitivity in the skin of the hind paw in the tumor-bearing limb. Conclusion: Even when the tumor is confined to a single load-bearing bone, CIBP drives a significant loss of activity, which increases with disease progression. Understanding the mechanisms that drive this reduction in activity may allow the development of therapies that allow CIBP patients to better maintain their activity and functional status. Abstract : Supplemental Digital Content is Available in the Text.Mice with bone cancer have reduced peak day/night activity. Therapeutically blocking this decline may improve the activity level of patients with painful bone metastases.