Irisin: A myokine with locomotor activity. (19th May 2015)

• Record Type: Journal Article
• Authors: Zhang, Weizhen; Chang, Lin; Zhang, Chao; Zhang, Ruthann; Li, Ziru; Chai, Biaoxin; Li, Jiyao; Chen, Eugene; Mulholland, Michael
• Is Part Of: Neuroscience letters. Volume 595(2015)
• Page Start: 7
• Page End: 11
• Publication Date: 2015-05-19
• Subjects: FNDC5 fibronectin type III domain containing 5 -- ICV intracerebroventricular -- XTOT total activity at x-axis -- XAMB ambulation at x-axis -- ZTOT total activity at z-axis; Irisin -- Locomotion -- Metabolism -- Central nervous system; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2015.03.069
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Central administration of irisin significant increase in locomotion in rats. Central irisin increases O2 consumption, CO2 production and heat production. Irisin coordinates locomotion with metabolic activity. Abstract: The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats. Central administration of irisin significantly increased the locomotion. Relative to control animals treated with IgG Fc peptide, rats receiving irisin demonstrated a marked increase in total travel distance, ambulatory counts and time, and vertical counts and time. These changes were associated with a significant decrease in resting time. Central treatment of irisin also induced significant increases in oxygen consumption, carbon dioxide production and heat production, indicating an increase in metabolic activity. Our study suggests that physical activity may signal to the central nervous system to coordinate locomotion with metabolic activity via irisin.