Role of P-Glycoprotein in Refractoriness of Seizures to Antiepileptic Drugs in Lennox-Gastaut Syndrome. (February 2015)

• Record Type: Journal Article
• Authors: Kumar, Achal; Tripathi, Deepak; Paliwal, Vimal Kumar; Neyaz, Zafar; Agarwal, Vikas
• Is Part Of: Journal of child neurology. Volume 30:Number 2(2015:Feb.)
• Page Start: 223
• Page End: 227
• Publication Date: 2015-02
• Subjects: Lennox-Gastaut syndrome -- refractory epilepsy -- P-glycoprotein -- multidrug resistance gene; Nervous system -- Diseases -- Periodicals; 618.928
• DOI: 10.1177/0883073814532545
• Languages: English
• ISSNs: 0883-0738

Abstract

Mechanism of seizure refractoriness to antiepileptic drugs in children with Lennox-Gastaut syndrome is not known. Efflux of antiepileptic drugs due to increased expression/function of P-glycoprotein, a multidrug efflux transporter protein on the cell surface is a proposed mechanism. The authors studied the expression/function of P-glycoprotein on peripheral blood mononuclear cells of 29 children with Lennox-Gastaut syndrome, 23 children with other epilepsies, and 19 healthy children. The authors found a higher P-glycoprotein expression/function in Lennox-Gastaut syndrome, a higher percent positive cells as compared to children with other epilepsy ( P < 0.001) and to healthy controls ( P = 0.012), higher P-glycoprotein expression as compared to healthy controls ( P = 0.003), a higher total P-glycoprotein expression (relative florescence intensity × percent positive cells) as compared to children with other epilepsies ( P < 0.001) and healthy controls ( P < 0.001), and a higher P-glycoprotein function as compared to children with other epilepsies ( P = 0.001) and healthy controls ( P = 0.002). These findings may explain seizure refractoriness to anti-epileptic drugs in Lennox-Gastaut syndome.