Surface characterization and drug release from porous microparticles based on methacrylic monomers and xanthan. (10th July 2015)

• Record Type: Journal Article
• Authors: Lungan, Maria-Andreea; Popa, Marcel; Racovita, Stefania; Hitruc, Gabriela; Doroftei, Florica; Desbrieres, Jacques; Vasiliu, Silvia
• Is Part Of: Carbohydrate polymers. Volume 125(2015)
• Page Start: 323
• Page End: 333
• Publication Date: 2015-07-10
• Subjects: Porous microparticles -- Methacrylic monomers -- Xanthan -- Surface morphology -- Theophylline; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.02.058
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: The surface morphology and drug release from new porous microparticles were investigated. The presence of xanthan influenced the surface morphology of microparticles. The surface roughness is influenced by the nature of the crosslinking agents. The microparticles with xanthan exhibited sustained theophylline release. Abstract: Porous crosslinked microparticles based on glycidyl methacrylate and xanthan were prepared by suspension polymerization and used for loading theophylline, a bronhodilatator drug, in order to obtain new drug delivery systems. The surface morphologies observed by means of SEM and AFM analysis demonstrated that microparticles show a spherical shape and are characterized by a porous structure. The presence of xanthan in the structure of microparticles leads to a decrease of surface roughness and pore diameters as well as to an increase of hydrophilicity degree compared to the micropaticles based only on glycidyl methacrylate. To analyze the in vitro release data various mathematical models were used, such as, first order, Higuchi model, Korsmeyer–Peppas model and Baker–Lonsdale model. Based on the highest values of the correlation coefficient, the analysis of the kinetic data indicate that drug release from G1 and X1 porous microparticles fits similarly well to the first order and Higuchi models and diffusion was the dominant mechanism of drug release.