MCR-click synthesis, molecular docking and cytotoxicity evaluation of a new series of indole–triazole–coumarin hybrid peptidomimetics. (5th April 2018)

• Record Type: Journal Article
• Authors: Pathoor, Rajeena; Bahulayan, D.
• Is Part Of: New journal of chemistry. Volume 42:Number 9(2018)
• Page Start: 6810
• Page End: 6816
• Publication Date: 2018-04-05
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj00032h
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : The design and synthesis of a new series of indole–triazole-coumarin hybrids as potential CDK2 inhibitors is described. Abstract : The design and synthesis of a new series of indole–triazole–coumarin hybrids as potential CDK2 inhibitors is described. The new hybrid molecules were synthesized via copper(i ) catalyzed [3+2] azide–alkyne cycloaddition and showed excellent binding affinity towards CDK2 kinase when subjected to virtual screening based on molecular docking. The molecular docking results were experimentally validated by cytotoxicity evaluation against human breast cancer cell line MCF-7 and western blot analysis. The IC50 value (17.5 μM) and binding affinity (−11.2 kcal mol −1 ) obtained for6a against MCF-7 cells are promising for the development of potential anticancer drugs based on these new molecules.