Metabolite amyloid-like fibrils interact with model membranes. Issue 36 (17th April 2018)

• Record Type: Journal Article
• Authors: Shaham-Niv, Shira; Rehak, Pavel; Zaguri, Dor; Kolusheva, Sofiya; Král, Petr; Gazit, Ehud
• Is Part Of: Chemical communications. Volume 54:Issue 36(2018)
• Page Start: 4561
• Page End: 4564
• Publication Date: 2018-04-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc01423j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Metabolite assemblies interaction with membranes further extend the "amyloid hypothesis" to include small metabolites which serve as amyloidogenic building blocks. Abstract : Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.