Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment. Issue 16 (3rd April 2018)

• Record Type: Journal Article
• Authors: Chun, Haejin; Yeom, Minjoo; Kim, Hyun-Ouk; Lim, Jong-Woo; Na, Woonsung; Park, Geunseon; Park, Chaewon; Kang, Aram; Yun, Dayeon; Kim, Jihye; Song, Daesub; Haam, Seungjoo
• Is Part Of: Polymer chemistry. Volume 9:Issue 16(2018)
• Page Start: 2116
• Page End: 2123
• Publication Date: 2018-04-03
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c8py00116b
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : This work describes efficient co-delivery system based on phenylboronic acid functionalized polymersomes. Abstract : Influenza A virus (IAV), which causes one of the most contagious diseases, is a global health concern and is responsible for seasonal epidemics and pandemics. Despite notable efforts towards developing antiviral agents and drugs, a vast majority of these, especially intracellular drugs, have shown limited efficacy due to non-specificity and low viability under physiological or endosomal conditions. Polymersomes consist of phenylboronic acid (PBA) pendant group polymers (PBASomes) and can act as drug carriers; they have sialic acid-targeting properties and can gain greater access to the intracellular space for the transport of antivirals within the host cell. Amphiphilic copolymers comprising methoxy-poly(ethylene glycol)- block -poly(phenylalanine) (mPEG- b -pPhe) formed polymersomes, which encapsulated mir-323a in the core and favipiravir in the exterior layer as hydrophilic and hydrophobic antivirals, respectively. For maximizing the cellular uptake of PBASomes via receptor-mediated endocytosis, the surface density of PBA was controlled with PBA-functionalized copolymers (PBA-PEG-pPhe). Combination therapy by employing polymersomes with PBA functional groups induced a synergistic effect against H1N1 virus infection in vitro . We believe that antiviral co-delivery using these polymersomes would provide better opportunities to improve transfection of therapeutic substances for IAV treatment.