High pressure NMR reveals conformational perturbations by disease-causing mutations in amyloid β-peptide. Issue 36 (19th April 2018)
- Record Type:
- Journal Article
- Title:
- High pressure NMR reveals conformational perturbations by disease-causing mutations in amyloid β-peptide. Issue 36 (19th April 2018)
- Main Title:
- High pressure NMR reveals conformational perturbations by disease-causing mutations in amyloid β-peptide
- Authors:
- Rosenman, David J.
Clemente, Nicolina
Ali, Muhammad
García, Angel E.
Wang, Chunyu - Abstract:
- Abstract : High pressure NMR reveals conformational biases in disease-causing variants of the Aβ monomer. Abstract : Here we present the high pressure NMR characterization of Aβ42 and two Aβ40 variants with Alzheimer-causing mutations E22G and D23N. While chemical shifts only identified localized changes at ambient pressure compared with Aβ40, high pressure NMR revealed a common site with heightened pressure sensitivity at Q15, K16 and L17 in all three variants, which correlates to higher β-propensity at central hydrophobic cluster (CHC) and faster aggregation.
- Is Part Of:
- Chemical communications. Volume 54:Issue 36(2018)
- Journal:
- Chemical communications
- Issue:
- Volume 54:Issue 36(2018)
- Issue Display:
- Volume 54, Issue 36 (2018)
- Year:
- 2018
- Volume:
- 54
- Issue:
- 36
- Issue Sort Value:
- 2018-0054-0036-0000
- Page Start:
- 4609
- Page End:
- 4612
- Publication Date:
- 2018-04-19
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c8cc01674g ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 6346.xml