Primary testicular natural killer/T-cell lymphoma: A CARE-case report and review of literature. Issue 12 (March 2018)

• Record Type: Journal Article
• Authors: Zhang, Wan-Lin; Ma, Shuang; Jug, Rachel; Li, Fan; Wang, Endi; Zhao, Huan-Yu; Xu, Hong-Tao; Cai, Lin; Yu, Cheng-Qian; Shen, Shuai; Yang, Lian-He
• Other Names: Ling. Shizhang section editor.
• Is Part Of: Medicine. Volume 97:Issue 12(2018)
• Publication Date: 2018-03
• Subjects: diagnosis -- NK/T-cell lymphoma -- pathology -- prognosis -- testicular; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000010181
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: Primary testicular natural killer (NK)/T-cell lymphoma is an extremely rare and highly aggressive lymphoid malignancy. At present, only 20 cases have been reported. Patient concerns: A 32-year-old Chinese man complained of discomfort and swelling of his right testicle for 3 months. Physical examination revealed a 10 × 10 × 9.5 cm mass on the right side of the scrotum area. Diagnoses: Pathologic evaluation showed effacement of normal testicular parenchymal architecture by small-to-medium-sized lymphoid cells with irregular nuclear profiles, and immunohistochemical studies positively expressed CD2, CD56, cytoplasmic CD3, granzyme B, perforin, and TIA-1. Therefore, the patient was diagnosed with primary testicular NK/T-cell lymphoma. Interventions: The patient underwent CHOP (cyclophosphamide (CTX), pirarubicin (THP-ADM), vincristine (VCR), and prednisolone (PDN)) chemotherapy. Outcomes: The patient relapsed 5 months after his initial presentation and died after an infection and gastrointestinal bleed. Lessons: Clinicopathological assessment of this rare case highlights the clinical and pathological features required to diagnose testicular NK/T-cell lymphoma. In addition, it highlights the dismal survival of these patients. We hope it may serve as a reference aiding prompt clinical diagnosis, which can hopefully improve the survival and quality of life of these patients.