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Β-Cyclodextrin as a supramolecular catalyst for the synthesis of dihydropyrano[2, 3-c]pyrazole and spiro[indoline-3, 4′-pyrano[2, 3-c]pyrazole] in aqueous medium. Issue 19 (6th May 2015)
Record Type:
Journal Article
Title:
Β-Cyclodextrin as a supramolecular catalyst for the synthesis of dihydropyrano[2, 3-c]pyrazole and spiro[indoline-3, 4′-pyrano[2, 3-c]pyrazole] in aqueous medium. Issue 19 (6th May 2015)
Main Title:
Β-Cyclodextrin as a supramolecular catalyst for the synthesis of dihydropyrano[2, 3-c]pyrazole and spiro[indoline-3, 4′-pyrano[2, 3-c]pyrazole] in aqueous medium
Graphical abstract: Abstract: Supramolecular β-cyclodextrin (β-CD) as a highly efficient, biodegradable, and reusable catalyst for the synthesis of pyranopyrazole derivatives is investigated via a one-pot four component reaction of aldehydes and isatins, hydrazine hydrate, malononitrile, and β-keto ester in H2 O–EtOH (9:1) at 80 °C for first time under neutral conditions.