The anti-ADAMTS-5 nanobody®, M6495, protects against cartilage breakdown in cartilage and synovial joint tissue explant models. (April 2018) - Siebuhr, A.; Bay-Jensen, A.-C.; Thudium, C.T.; Karsdal, M.A.; Serruys, B.; Werkmann, D.; Michaelis, M.; Ladel, C.; Lindemann, S.