Impact of diabetes and diastolic dysfunction on exercise capacity in normotensive patients without coronary artery disease. (May 2015)

• Record Type: Journal Article
• Authors: Gürdal, Ahmet; Kasikcioglu, Erdem; Yakal, Sertac; Bugra, Zehra
• Is Part Of: Diabetes & vascular disease research. Volume 12:Number 3(2015:May)
• Page Start: 181
• Page End: 188
• Publication Date: 2015-05
• Subjects: Type 2 diabetes -- diastolic dysfunction -- exercise capacity -- cardiopulmonary exercise test; Diabetic angiopathies -- Periodicals; 616.462005
• DOI: 10.1177/1479164114565631
• Languages: English
• ISSNs: 1479-1641

Abstract

Objective: The aim of this study was to determine the impact of diabetes and diastolic dysfunction on exercise capacity in asymptomatic, normotensive patients with type 2 diabetes without coronary artery disease. Methods: A total of 43 type 2 diabetes patients (age: 50 ± 5 years) and 20 healthy controls (age: 48 ± 4 years) were enrolled. Diastolic function was investigated by conventional pulsed-wave (PW) Doppler and tissue Doppler imaging (TDI). Exercise capacity was evaluated with cardiopulmonary exercise testing (CPET). Results: In patients with type 2 diabetes, increase in resting heart rate (HR-rest) ( p = 0.013), decrease in maximum heart rate during exercise (HR-max) ( p < 0.001) and exercise time ( p < 0.001) compared with controls were significant. Patients had significantly increased minute ventilation volume (VE)/maximum carbon dioxide discharge (VCO2 ) ratio ( p < 0.001), decreased maximum oxygen consumption (VO2 -max) ( p < 0.001), oxygen consumption at anaerobic threshold (VO2 -an) ( p < 0.001) and maximum carbon dioxide discharge (VCO2 ) ( p < 0.001) compared to controls indicating significantly reduced exercise capacity. HbA1c was inversely correlated with VO2 -max ( r = −0.456, p < 0.01) independent of the absence or presence of mild diastolic dysfunction. Conclusion: Exercise capacity was found to be significantly decreased in normotensive patients with type 2 diabetes without coronary artery disease, and this decrease was independent of diastolic dysfunction.