The Accuracy of C-Reactive Protein, Procalcitonin, and s-TREM-1 in the Prediction of Serious Bacterial Infection in Neonates. (May 2015)

• Record Type: Journal Article
• Authors: Stein, Michal; Schachter-Davidov, Anita; Babai, Ilan; Tasher, Diana; Somekh, Eli
• Is Part Of: Clinical pediatrics. Volume 54:Number 5(2015)
• Page Start: 439
• Page End: 444
• Publication Date: 2015-05
• Subjects: C-reactivel protein -- procalcitonin -- s-TREM-1 -- sepsis -- neonate; Pediatrics -- Periodicals; 618.920005
• DOI: 10.1177/0009922814553435
• Languages: English
• ISSNs: 0009-9228

Abstract

In this prospective study, we examined the usefulness of C-reactive protein (CRP), soluble triggering receptor expressed on myeloid cells (s-TREM-1), and procalcitonin (PCT), in identifying serious bacterial infection (SBI) among neonates. Infants younger than 3 months with suspected SBI were included and serum concentrations of CRP, PCT, and s-TREM-1 were determined. Results . A total of 112 patients (19 with SBI and 93 with negative cultures) were evaluated. There were no statistical differences between the 2 groups regarding age, presence of fever, and serum concentrations of the different biomarkers. Performance of the different biomarkers were as follows: The sensitivities were 45%, 55%, and 82% for CRP, PCT, and s-TREM-1, respectively, whereas the specificities we 82%, 75%, and 48% for CRP, PCT, and s-TREM-1, respectively. The areas under the receiver operating characteristic curve were 0.6, 0.63, and 0.61, for CRP, PCT, and s-TREM-1, respectively. Conclusions . In real-life pediatric practice, none of the tested biomarkers was sufficiently accurate to serve as a reliable indicator for the identification of SBI in neonates.