The altered Granger causality connection among pain-related brain networks in migraine. Issue 10 (March 2018)

• Record Type: Journal Article
• Authors: Ning, Yanzhe; Zheng, Ruwen; Li, Kuangshi; Zhang, Yong; Lyu, Diyang; Jia, Hongxiao; Ren, Yi; Zou, Yihuai
• Other Names: Gharaei. Helen section editor.
• Is Part Of: Medicine. Volume 97:Issue 10(2018)
• Publication Date: 2018-03
• Subjects: Granger causality analysis -- migraine -- pain-related networks -- resting-state functional magnetic resonance imaging; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000010102
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: Numerous fMRI studies have confirmed functional abnormalities in resting-state brain networks in migraine patients. However, few studies focusing on causal relationships of pain-related brain networks in migraine have been conducted. This study aims to explore the difference of Granger causality connection among pain-related brain networks in migraine without aura (MWoA) patients. Twenty two MWoA patients and 17 matched healthy subjects were recruited to undergo resting-state fMRI scanning. Independent component analysis was used to extract pain-related brain networks, and Granger causality analysis to characterize the difference of Granger causality connection among pain-related brain networks was employed. Seven pain-related brain networks were identified, and MwoA patients showed more complex Granger causality connections in comparison with healthy subjects. Two-sample t test results displayed that there was the significant difference between right-frontoparietal network (RFPN) and executive control network (ECN). This study indicates that the specific intrinsic brain Granger causality connectivity among pain-related networks in MwoA patients are affected after long-term migraine attacks.